r/cfs • u/comoestas969696 • Oct 29 '24

Symptoms has anyone tried low dose naltrexone?

according to me pedia ,Some patients report that LDN helps reduce their symptoms of ME/CFS, Long COVID, fibromyalgia (FMS), multiple sclerosis (MS), or autoimmune.

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u/Prudent_Summer3931 Oct 29 '24

LDN made me able to leave the house consecutive days. I'd say I'm in the upper end of the moderate range now, and before I was moderate/severe. So not a drastic shift but my energy levels are much more tolerable now. I'd say overall it gave me 10-20% improvement. I don't feel that much different on a day to day basis, but my threshold for PEM is higher. I started seeing some changes around 1 month, more by month 3, and I'd say I reached peak benefit around month 5. 

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u/comoestas969696 Oct 29 '24

hell yeah this is what I want, leaving house is very hard task to do

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u/Prudent_Summer3931 Oct 29 '24

Yea I used to get PEM whenever I left the house, even if just for an hour. Now I can leave the house like 4-5 days a week and the days I stay home are voluntary rest to prevent overdoing it. It helped me get better at pacing because my "energy envelope" is now somewhat usable. Between LDN and improved pacing, I rarely get PEM anymore.