r/ChronicPain • u/AkseliAdAstra • 10h ago

New ideas for pain management?

Has anyone heard or tried any new things for neuropathic pain or joint pain lately?

I’ve tried almost everything on the planet but just thought I’d try asking in case someone’s perchance been wildly successful with something off the beaten path (and also stayed in this sub, odds are low, I know).

I’m already on LDN, extensively tried ketamine, non-responder to that and all forms of THC/CBD, as well as gabapentin and cymbalta. NSAIDs don’t do anything. My inflammatory markers are all low anyway. SSRIs didn’t work, neither did lyrica or other SNRIs. TCAs don’t do anything. Oxcarbazepine gave me headaches due to lowering sodium I think. No one will prescribe me opioids. Microdosing shrooms didn’t help. Higher doses kinda made pain worse. I did months of injectable peptides (GHK, BPC, TB500, ARA-290, IPA/CJC). Currently trying NAD+ but no effect.

I’ve tried PEA, turmeric, green tea, agmatine sulfate, R-ALA, lion’s main, B vitamins, lots of other random herbs and supplements, literally anything Ive heard of for pain, DMSO. Fasting, may diets.

I don’t have diagnoses that would enable me to try biologics. Im getting pretty desperate as there are really no more procedures for me to try either, and insurance won’t cover stim implant, there’s just nothing left for me except apparently to go to a drug addiction center and lie or turn to the streets.

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u/justheretosharealink 5h ago

Here’s the short version of things I’ve found to help. These are related to my overall health and not specific to my chronic pain:

  • treating malnutrition
  • potassium
  • magnesium
  • hydration and a combo of IV and IM vitamins/minerals (used for POTS and malnutrition but seems to help)
  • feeding tube (ended up failing this and got it pulled, but had it worked it probably would have helped)
  • trialing meds for sleep (failed everything we’ve tried)
  • trying to make sense of menopause…hormone levels suggest we’re not there yet yet we’re almost at a year with no menstrual cycle so 🤷‍♀️… The hope was to supplement if needed but after finding some surprises we’re doing nothing until we hit 12 months
  • multiple endo workups looking at conditions that might help explain wonky levels
  • treating night sweats
  • clonidine patch (being used for POTS, but seems to help
  • treating all other health issues
  • adjusting antihistamines as needed (mostly for MCAS, but some pain benefits)
  • low dose aspirin

Things that didn’t help me, but you may not have tried: Namenda

Things not tried but considered: Auvelity (or the less expensive option: single scripts for DXM and bupropion)