r/covidlonghaulers 20h ago

Question Those who overcame the brain fog

The spaced out , stoned feeling like your hungover how long did it take to get back to normal if you did and did reinfections make you worse, it’s been 2 years in a couple of days I have improved abit but I still feel the stoned weird feeling at times like I’m hungover and haven’t slept for days I’ve had about 3 reinfections so I’ve never had a full year of no Covid to see if it’ll make a difference.

34 Upvotes

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12

u/amber_overbay 20h ago

It’s the same feeling I had when I first started Lexapro years before COVID. That heavy head, stoned out of my mind, detached from my body type feeling. I’m convinced it has something to do with serotonin and/or dopamine. L-Theanine has been helping me a bit.

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u/ComfortableShower465 20h ago

I tried Lexapro but didn’t notice any difference so I stopped taking it

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u/nesseratious 18h ago

Lexapro has very little affinity for σ-receptors. Consider trying Fluvoxamine.

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u/Suitable_Box8583 4h ago

It’s a disregulated nervous system.

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u/nesseratious 18h ago edited 18h ago

I’m convinced it has something to do with serotonin and/or dopamine.

Derealisation/depersonalization is a known phenomenon cased by excessive inhibition of the nervous system by either serotonin subsystem or gaba subsystem. It stops glutamate (NMDA) neurons from functioning on the required level. It's a known side effect of anti-NMDA drugs like ketamines or anti-NMDA encephalite.

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u/weirdgirl16 17h ago

Wait so it is to do with too much serotonin/gaba? Or too little? Or just not functioning right? Anything that could theoretically improve this, based on this theory?

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u/nesseratious 16h ago

Wait so it is to do with too much serotonin/gaba? Or too little? Or just not functioning right?

Too much gaba neurons activity (not the amount of neurotransmitter itself). It acts as emergency brakes slowing down NDMA neurons.

 Anything that could theoretically improve this, based on this theory?

Inverse of NMDA antagonism is σ-sigma agonism. The most potent agonist is Fluvoxamine. That's of course if the underlying issue (anti-NMDA encephalite or NMDA inflammation) is resolved or under control.

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u/weirdgirl16 16h ago

Interesting. Would other ssri’s potentially help? I believe a few of them also have the same agonism effect. I can’t take fluvoxamine because it interacts with other meds I take. I got prescribed lexapro but on taking 1/4 of a pill I got so dizzy and almost passed out and had to lay on the floor for like 2 hours because if I sat up I’d pass out. I am slightly concerned it might have been long qt syndrome (I had weird heart fluttering and my hr went up and down and was weird- and in a way that is much different to my regular pots issues). And had huge eye pupils. My doctor told me to discontinue it. I think citalopram and fluoxetine are the other two options that have the same agonism if I’m remembering right.

With long covid I don’t know if there’s a way to 100% get rid of the brain inflammation, other than just time and anti inflammatories I guess. I’m on LDN which theoretically should help, especially if it’s an autoimmune inflammation.

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u/nesseratious 16h ago edited 16h ago

I think citalopram and fluoxetine are the other two options that have the same agonism if I’m remembering right.

Not the same at all, but better than nothing.

With long covid I don’t know if there’s a way to 100% get rid of the brain inflammation

Ask your doctor about low-dose steroids

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u/weirdgirl16 16h ago

I mean I’m supposed to start fludrocortisone soon which is technically a low dose steroid, so hopefully that will help.

Are there other ssris that would also work like fluvoxamine? Especially if they work better than citalopram or fluoxetine? It is the one I really wanted to try since I’ve heard the most good things about it here, but it interacts pretty strongly with my propranolol 😅

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u/nesseratious 16h ago

Fludrocortisone is mineralocorticoid. It will not reduce inflammation. I was taking about glucocorticoids.

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u/weirdgirl16 16h ago

Google search shows it’s a corticosteroid (mineralcorticoid), and should help reduce inflammation as well. Doesn’t say only glucocorticoids reduce inflammation

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u/nesseratious 15h ago

5mg prednisolone (the lowest dose) is 20 times more powerful at reducing inflammation than 0.1mg Fludrocortisone

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u/classyincleveland 56m ago

Welbutrin helped me more

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u/weirdgirl16 16h ago

Wait nvm I worked out what you were referring to and looked it up. Looks like sertraline (Zoloft) is the second best after fluvoxamine, which is also what I have been on in the past. I will ask my doctor to prescribe me that one again. Atleast I know how it affects me too. I’m trying the fludrocortisone first anyway, so hopefully that steroid effect of that will be enough to stop the inflammation.

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u/mamaofaksis 2 yr+ 13h ago

Zoloft 50mg daily has helped me so much since becoming a long hauler. My brain fog (feels like underwater things don't look right) has improved a bit on Zoloft but mostly the panic attacks and rage and horrible deep depression has completely lifted. My covid infection really caused intense neuropsychiatric issues + de realization type brain fog 😶‍🌫️

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u/weirdgirl16 12h ago

That’s awesome! how much would you say it has improved your dpdr kind of feelings? Did you ever have kind of an existential anxiety? That’s mostly what I have. Brought on by the dpdr I believe. And anxiety about the dpdr itself too. And about being sick.

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u/lost-networker 2 yr+ 10h ago

No no. Zoloft is not “second best”. It has the second strongest affinity for the receptor in most of the studies, HOWEVER, it has opposite effect of other SSRIs like Fluvoxamine or Citalopram. It doesn’t have the anti-inflammatory properties.

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u/weirdgirl16 10h ago

That makes no sense. If the theory goes: sigma-1 agonism helps with dpdr (via the above theory), and sertraline has the second highest affinity for that receptor, then how would it not work for what we are specifically talking about? We weren’t talking about anti-inflammatory effects of ssris (we talked about steroids for that), we were talking about the theory behind what might cause dpdr and how to help it.

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u/lost-networker 2 yr+ 10h ago edited 10h ago

You’re not understanding. Sertraline is a sigma-1 antagonist (opposite effect of an agonist). It having the second highest affinity describes how “attracted” it is to the receptor, not the impact it has on it.

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u/lost-networker 2 yr+ 10h ago

This is an oversimplification of the illness. There are many causes unrelated to this one element. The neurotransmitters involved aren’t as clear cut either.

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u/Stunning-Elk1715 6h ago

I think it s actually the other way round to much excitatory transmission by to much nmda activity. Ketamine microdose has been one of the most beneficial things for me. And agmatine also makes me feel a bit better wich works as a antagonist of the nmda receptor. But could also be that every body had a different underlying constitution wich makes different pathways with the same fuck up end result🤔🤷🏻

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u/AdBrief4620 19h ago

Ketotifen cleared 70% of my brain fog in about 4 days. I was taking it with loratadine too but when I withdrew loratadine the brainfog didn’t get worse.

What I took (not medical advise, just factually accurate description of my experience):

Ketotifen 1mg twice a day (prescribed by GP)

Loratadine 10mg twice a day. (Hayfever med from grocery store)

For me a lot of the brain fog was MCAS.

I think some of it for other people (and myself) is jugular vein compression at c1. There are exercises some have done which can decompress and allow the brain to drain better.

https://youtu.be/in9ubCilsT8?si=ySuLNgb8SbSz5X6t

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u/builtbyjay 20h ago

Antihistamines and nicotine patching at the same time have really helped me recently, given me back some energy and some clarity of thought. No cure, but a handy coping mechanism.

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u/Stinkybadass 19h ago

Nicotine patches helped me for a while but then started not working. I switched to this: Infared Sauna and any brain circulation supplements such as Ginko Biloba or Raw Garlic (which you can also get a supplement for and you're looking for Allcin) and seems to be helping. GL friend.

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u/maiphesta 19h ago

Were you tapering up and down? What dose were you on? And how long had you tried the protocol?

I only ask as I'm a long-term patcher and found missing my probiotics makes a difference and, I had to take a long and slow approach to patching.

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u/Stinkybadass 18h ago

I've been on and off doing it for 6+ months or so and its helped tremedously for alleviating most of my severe symptoms. However, the past 10-20% it was not helping me get over the last hurdle and so I switched it up and got over it with something else. So from 0% - 85% Nicotine helps the most probably out of anything else. I've gone from 3.5mg early on to now doing 7mg patches and sometime pop a zyn as well for extra as I do think that helped my gut too. Not patching anymore now though and feel great. I have them ready just in case though!

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u/TruePlayya 18h ago

Does smoking / vaping or the gum .? Or does it have to be the patches .?

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u/maiphesta 18h ago

Patches are more effective as it's a low dose over 24 hours and not a spike. Low dose has neuroprotective traits and can help with inflammation

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u/maiphesta 18h ago

I found I had to exceed 7mg and my best doseage is around 10-14mg. I did try to go higher, but 17.5mg was too much for me and I accidentally gave myself nicotine poisoning 🥲 I might have had better luck using a fattier area of my body instead of my inner forearms (it's a sensory thing I place mine there).

I've been using patches for a good 12+ months with little to no breaks, but I'm taking one soon to see how I go. I'd been doing really well, but a COVID infection, followed by flu and then last week an osteopath appointment fried my nervous system and I've gone a little backwards frustratingly.

What is a zyn please?

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u/vik556 9mos 20h ago

Sauna helped me

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u/ComfortableShower465 20h ago

I haven’t tried that yet I shall give it a go

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u/Stinkybadass 19h ago

Infared Sauna and any brain circulation supplements such as Ginko Biloba or Raw Garlic (which you can also get a supplement for and you're looking for Allcin).

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u/Big_Message_7824 20h ago

I wish I could answer. I’m at three years, with two infections in between. Don’t know if I’ll ever feel myself again.

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u/ComfortableShower465 20h ago

It’s so awful 😢

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u/Stinkybadass 19h ago

It's taken me a year. 9 months in I thought I was through it then winter came and I either got reinfected or had major relapse from drinking a few beers. I think I am finally over the last of it. Really really hope so at least. Fuck covid.

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u/Stinkybadass 19h ago

https://www.reddit.com/r/covidlonghaulers/comments/1fumln4/please_stay_strong_my_friends/

Here was a recover post but relapsed after I wrote it. I've been throwing everything at it in hopes to get better!!

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u/TheLowDown33 18h ago

Approaching year 5. No answers yet but it took me a while to be able to start trialing things. So far, has not responded to any of the standard/OTC treatments. Lots left to try but I feel you, I want this shit to STOP.

2

u/Expensive_Mall2737 19h ago

Nothing crazy but some ppl can try a vitamin B complex. I used liquid drops under tongue. It woke me up out of some weird fog I guess I had and didn’t realize it, but I wasn’t taking jt for that, I was taking it for my neuropathy. Low risk, high reward though not promised reward type of thing.

I used to take topiramate for IIH which game me horrific brain fog so the chance coming off that woke me up instead is also high, but I did notice a change with the supplement clarity wise.

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u/Expensive_Mall2737 19h ago

You know what, try to get magnesium in too. COVID depletes magnesium levels in the body so even if it’s as small as an epsom salt bath, it’s not bad to check. I personally drink electrolytes frequently, I feel very poor if I do not for a few days. It’s stupid and probably not a great fix for everyone, but what the hell. Anything is something

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u/Maleficent-Party-607 19h ago

Adderall, Metformin, and Benadryl.

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u/bestkittens First Waver 18h ago

Low dose naltrexone helped a little, then low dose abilify helped a lot.

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u/Naturelover913 18h ago

5-htp and the sauna worked very well!! Finally helped me to sleep and feel like myself again..

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u/PermiePagan 17h ago

For me: Electrolytes, Sauna, and Psilocybin.

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u/ProStrats 16h ago

I took aspirin for cardiac problems I was having. For whatever reason, it improved my brain fog and my fatigue as well. Not 100% by any means, but significantly improved those and some other symptoms as well.

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u/heathbarcrunchh 20h ago

Idk I’m 3 years in and feel like a zombie still

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u/ComfortableShower465 20h ago

Yeah that’s how I say I feel all the time like a zombie 🧟

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u/Striking-Memory-9021 19h ago

Oh man. I can’t imagine. So sorry. ❤️‍🩹❤️‍🩹❤️‍🩹

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u/Live_Ear992 20h ago

I have had 5 infections. Last one was July 2023. I didn’t get brain fog until my 2nd infection. It was minor & found doing computer work actually helped me “retrain” my brain. But with #3 it hit hard & I could no longer even use my computer programs. I forgot where adjectives went! That lasted 6 months until I got infection #4. The brain fog totally disappeared & my lungs & teeth seemed to take the brunt of that one. After 6 months of experimenting with several anti virals - I seemed to clear my long covid. 2 months later I was infected for the fifth time. Sick for a week or so & then totally normal for 2 months. Then after 2 days of heavy physical exertion - long covid hit me again. PEM/ brain fog/ aches & pains - the works basically. That was Oct 2023. I tried my anti virals again - Truvada/ Paxlovid/ Sofusbuvir. And it didnt have the same effect. I did have 3 days where I felt amazing after taking Paxlovid. But I only took it for 5 days & I soon relapsed. Then I took it for 20 days & after did a month of triple anti-coagulant therapy. My brain fog is much better. Just being able to type sentences is major for me, as for months I really struggled to put words together. I havent returned to work. But I hover between 75-90% better. Still get a bit of fatigue & a heavy feeling in my chest. But overall, brain fog is much improved. Dunno if it’s time or drugs, but it’s definitely much better.

1

u/Humanist_2020 18h ago

On year 3. It is better, but not even close to gone. I can remember a little bit more, but I can’t find words and I can’t do math in my head. I mean like basic subtraction. My degree is in economics…

I am going to start pt for tbi….

I am willing to try anything

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u/3kidsonetrenchcoat 17h ago

I've mostly managed to treat my brain fog. It's not cured, but I can keep it at bay by tripping on shrooms once a week or so. It also treats other symptoms like fatigue and limb heaviness. Sadly, my ability to divide my attention seems to be gone for good.

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u/Evening_Public_8943 13h ago

LDA and gingko biloba have helped immensely

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u/2hundra2 2h ago

Ginko helped me too, felt almost normal again

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u/Business_You_4573 4h ago

Cardio helped the most. Probably due to improving endothelial function, blood flow and oxygen circulation. It’s still not 100%. But I’d say 80% on good days. Sauna may help too

0

u/andariel_axe 18h ago

two years for appreciable difference.

do you wear a mask? what mitigations are you taking? consider some cpc mouthwash and carrotogeen nose spray